5 0 and 3 0 region variability in the dopamine transporter gene ( SLC 6 A 3 ) , pesticide exposure and Parkinson ’ s disease risk : a hypothesis - generating study
نویسندگان
چکیده
Department of Environmental and Occupational Health Sciences, Department of Epidemiology and Department of Neurology, University of Washington, Seattle, WA 98105, USA, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and Department of Human Anatomy, Pharmacology and Forensic Sciences, University of Parma Medical School, Parma, Italy
منابع مشابه
5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study.
The dopamine transporter gene (SLC6A3) is a candidate gene for Parkinson's disease (PD) on the basis of its critical role in dopaminergic neurotransmission. Previously, we identified 22 SNPs in the 5' region of SLC6A3, which segregate as eight haplotypes that differ in transcriptional activity when transfected in rat dopamine-producing cells. In the present work from a case-control study size o...
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The exact role of dopamine transporter gene (DAT1) in the pathogenesis of bipolar disorder type 1 (BD) is not understood. In the present study, we aimed to evaluate the possible association between 30, 40 and 63 bp variable number tandem repeat (VNTR) polymorphisms of DAT1 gene and the risk of type 1 (BD) in a sample of Iranian population. This case-control study was performed on 152 BD patient...
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BACKGROUND Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk. MATERIALS METHODS In 324 incident PD patients and 334 population controls from our rural California case-control study, we genotyped rs2652510, rs2550956 (for the DAT 5' clades), and the 3' variable number...
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تاریخ انتشار 2006